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Stopping and restarting certain GLP-1s to lose weight may make the drug less effective
1+ day, 1+ hour ago (360+ words) A preclinical study reveals that people seeking weight loss from GLP-1s may need to consistently take the medication long term. GLP-1s have surged in popularity with approximately 1 in 8 adults in the United States saying they have used them for weight…...
The journey to medical residency, aided by those who've been there
5+ day, 8+ hour ago (494+ words) Medical students face a gauntlet of travel for interviews before their match'but Penn alumni mentors help out at this and other key career stages. When fourth-year medical student Holly Cordray stepped off the plane in Denver for another long round…...
To deliver hospital-level care at home, practice makes perfect
5+ day, 12+ hour ago (1776+ words) Years of planning come to fruition as Hospital at Home teams test run a new era of patient care devoted to better outcomes and fewer readmissions. Mr. Three was lying in a bed, his face contorted in frustration. He had…...
New KIR-CAR T cell therapy shows promise in multiple solid cancers
1+ week, 2+ day ago (378+ words) The first-of-its-kind Phase I clinical trial uses a CAR T cell therapy modeled after natural killer cells and designed to limit T cell exhaustion. As Penn CAR T cell therapy pioneer Carl June, MD, the Richard W. Vague Professor in Immunotherapy,…...
Penn Medicine, Children's Hospital of Philadelphia team awarded Breakthrough Prize for developing gene therapy for inherited blindness
1+ week, 4+ day ago (682+ words) LOS ANGELES" Their discovery started with a group of blind dogs living at a vet school. Now, the work has been awarded the prestigious Breakthrough Prize at the "Oscars of Science." Their work blazed a trail for the more than…...
Blood test predicts kidney failure risk to Black Americans years before onset
2+ week, 1+ hour ago (411+ words) A Penn study identifies disease risk among those carrying the APOL1 variant before kidney function declines. A new blood test can identify which individuals of African ancestry carrying high-risk APOL1 gene variants are most likely to develop kidney failure, years before clinical…...
A home away from home for transplant patients and families
2+ week, 7+ hour ago (509+ words) The Clyde F. Barker Penn Transplant House offers a comforting and affordable refuge for transplant patients and families'with community and hope. The Rosenbaums, who live in Florida, still return to the Barker House on occasion, staying there when appointments bring them…...
How estrogen in the brain impacts stress and trauma response
3+ week, 8+ hour ago (613+ words) New research reveals how estrogen levels in the brain influence vulnerability to stress-related memory problems, helping explain sex differences in PTSD risk. Estrogen is widely known to support learning and memory. This study found that high levels of estrogen in…...
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3+ week, 21+ hour ago (15+ words) Azacitidine and venetoclax (AZA/VEN) for older adults with AML ineligible for intensive chemotherapy'Penn Medicine...
Improving science and care for early pregnancy loss
3+ week, 4+ day ago (590+ words) Courtney Schreiber, MD, MPH, challenged the status quo of care through research and found PEACE for the unseen women undergoing first-trimester miscarriage. "I remember thinking, "This is it," Schreiber said. "I will no longer give a treatment that doesnt work…...