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Restoring Gut Barrier Function in Crohn's by Targeting ISR Activation
10+ hour, 44+ min ago (357+ words) It's a paradigm shift from the way we've thought about the disease," said senior author Seema Khurana, Ph D, a professor of biology and biochemistry at the University of Houston. Existing therapies primarily manage symptoms because we don't know what…...
FDA Accepts Label Expansion of Immuno-Oncology Drug to Lupus
4+ hour, 47+ min ago (589+ words) A decision for the supplemental Biologics License Application for Gazyva (obinutuzumab) to treat systemic lupus erythematosus is expected by December By Jonathan D. Grinstein, Ph D SLE is not a single-pathway disease. It is a systemic autoimmune condition in which the…...
AI Model Can Detect Very Early Pancreatic Cancer from CT Scans
3+ hour, 9+ min ago (307+ words) An artificial intelligence (AI) model developed at the Mayo Clinic can detect very early signs of pancreatic cancer from CT scans of the abdomen that are normally invisible to the human eye. Researchers tested the Radiomics-based Early Detection MODel (REDMOD)…...
Face Photos Offer Window on Cancer Survival
10+ hour, 50+ min ago (259+ words) An artificial intelligence tool could identify patients at increased risk of death after cancer treatment from their faces, research findings suggest. Patients with faces that aged rapidly between radiotherapy treatments according to the tool had a decreased chance of survival,…...
Multi-Cancer Early Detection Goes Global and Gets Personal
14+ hour, 57+ min ago (500+ words) Tom Beer, MD, Abbott Cancer Diagnostics' CMO for MCED, discusses how the combo of protein and ct DNA biomarkers changes the race to find cancer sooner By Jonathan D. Grinstein, Ph D The video starts simply: a couple at home, music…...
Obesity Leaves Lasting DNA Methylation Memory in Immune Cells
1+ day, 5+ hour ago (683+ words) A new study suggests that obesity leaves a durable molecular imprint on the immune system, one that persists long after weight loss and may continue to influence disease risk. Researchers at the'University of Birmingham'report that key immune cells retain an…...
Removing Harmful Protein from Blood Helps Women with Preeclampsia
1+ day, 11+ hour ago (337+ words) An early stage clinical study shows removing a protein known as soluble Fms-like tyrosine kinase 1 (s Flt-1) from the blood of pregnant women with early stage, severe preeclampsia seems to help both mothers and babies with no significant side effects....
PD-L1 Inhibitors for Cancer Treatment Could Be Repurposed to Treat Bone Loss in Obesity
1+ day, 10+ hour ago (577+ words) Inside Precision Medicine Bone loss related to obesity is partly caused by changes inside the bone marrow fat compartment that reshape immune signaling and increase osteoclast formation, according to researchers at the Maine Health Institute for Research. In a study…...
Mailed FIT-DNA Test Improves Colorectal Cancer Screening Rates in U. S.
1+ day, 14+ hour ago (352+ words) A screening test mailed to participants that looks for blood and DNA markers of cancer in human stool, Fecal immunochemical test (FIT)-DNA, was more popular than a test looking for blood alone, show results from a study carried out…...
Fibroblast Subset Directs Immune Cell Positioning in Lymph Nodes
4+ day, 11+ hour ago (620+ words) Researchers at the'University of Lausanne'have identified a specialized fibroblast population that actively organizes immune cell interactions within lymph nodes, revealing a key mechanism underlying effective T cell responses to infection and cancer. The study, published in'Immunity, shows that stromal cells,…...