2+ day, 13+ hour ago   (252+ words) An oral small molecule that increases energy expenditure rather than suppressing appetite produced substantial weight loss while preserving lean mass in mouse models of obesity, suggesting a potentially complementary strategy to GLP-1–based therapies. In mice with high-fat diet-induced obesity,…...

2+ day, 13+ hour ago   (225+ words) Rare disease specialist Ultragenyx’s gene therapy Genglycos has received accelerated approval from the FDA for treatment of glycogen storage disease type Ia (GSDIa), a rare metabolic condition. This marks the fifth FDA approval for the California-based biotech, which has already…...

2+ day, 13+ hour ago   (327+ words) The study focuses less on the primary tumor and more on what makes disseminated cancer cells grow into clinically dangerous metastases. Many TNBC patients can have their primary tumor treated successfully, but outcomes worsen sharply once the disease spreads to…...

2+ day, 15+ hour ago   (306+ words) “For years, we believed there were hard limits on how much donor mismatch could be safely tolerated,” said Antonio Martin Jimenez Jimenez, MD, associate professor of clinical medicine at the University of Miami’s Sylvester Comprehensive Cancer Center. “These findings suggest…...

3+ day, 13+ hour ago   (445+ words) Researchers at Washington State University (WSU) have developed an electronic skin that can sense temperature and pressure, potentially helping amputees regain a sense of touch through their prosthetics. A study published in Cell Reports Physical Science found that this technology…...

3+ day, 11+ hour ago   (219+ words) CKM syndrome describes the interconnected relationship among obesity, diabetes, chronic kidney disease, and cardiovascular disease. It is categorized by stages that reflect a person’s risk factors, ranging from 0 (no risk factors) to 4 (existing cardiovascular conditions such as coronary heart disease,…...

3+ day, 13+ hour ago   (401+ words) Mayo Clinic researchers have quantified the risk that pancreatic cysts will progress to pancreatic cancer based on the number of worrisome features they display. Published in Gastroenterology, the findings could help doctors better assess which cysts are most likely to…...

3+ day, 13+ hour ago   (397+ words) Researchers at Weill Cornell Medicine have identified a previously unknown link between amino acid metabolism and prostate cancer’s resistance to hormone therapy. Published in Nature Metabolism, the preclinical study found that prostate cancer cells can hijack the metabolism of two…...

4+ day, 10+ hour ago   (283+ words) For the study, the researchers used 16S ribosomal RNA sequencing to analyze paired oral and fecal samples from 77 people with treatment-naïve gastric cancer, 86 with treatment-naïve colorectal cancer, 215 with metabolic disorders, and 129 healthy controls. They then created a mouth-to-feces (MF) index, which…...

4+ day, 15+ hour ago   (309+ words) “We had to think about how to balance stability and flexibility so it could oscillate millions and millions of times but maintain the desired mechanical behavior,” said Pengfei Chen, PhD, postdoctoral scholar in materials science and engineering at UW–Madison....