2+ day, 1+ hour ago   (760+ words) Researchers at the Keck School of Medicine of USC have developed an open-source, AI-assisted MRI analysis pipeline capable of processing thousands of preclinical stroke scans with expert-level accuracy, addressing a critical reproducibility challenge in the translation of experimental stroke therapies…...

2+ day, 3+ hour ago   (962+ words) Researchers have shown in mice that vaccine nanoparticles with greater avidity produce stronger, longer-lasting immune responses and give rare broadly neutralising antibody precursor B cells a competitive advantage in germinal centres, adding a new engineering variable to HIV vaccine design....

3+ day, 3+ hour ago   (984+ words) Why do some colorectal cancers resist immunotherapy? Analysis of patient tumour samples has identified a population of fibroblasts that could help explain treatment resistance. Immune checkpoint blockade works by removing inhibitory signals that limit T-cell activity, allowing immune cells to…...

3+ day, 1+ hour ago   (378+ words) A Mass General Brigham-led study has identified Meis2 as a candidate gene capable of restoring impaired neuronal plasticity and reducing seizures in a preclinical model of neurodevelopmental disorders. Researchers at Mass General Brigham have identified a gene that may help restore…...

3+ day, 2+ hour ago   (597+ words) A comprehensive new review assesses the emerging landscape of nanoparticle-based delivery systems and maps the translational challenges that must be resolved before nanomedicine can become a routine component of clinical care. Glioblastoma is currently one of the hardest cancers to…...

3+ day, 22+ hour ago   (682+ words) A modular tissue-chip platform incorporating ultrathin human cell membranes and real-time sensors has been accepted into the FDA’s ISTAND pilot programme, marking a significant regulatory step towards qualifying the technology as a drug discovery tool capable of predicting immunotherapy-associated toxicities…...

4+ day, 1+ hour ago   (532+ words) Researchers have engineered a genetic system capable of detecting the mechanical softness of tumour cells and reprogramming that physical state into a synthetic antigen target, offering a new conceptual framework for tackling treatment-resistant cancer stem-like cell populations in solid tumours....

5+ day, 5+ hour ago   (852+ words) Professor Joseph C. Wu of Stanford University explains how stem cells, human-relevant models and AI are helping researchers predict which drug candidates are most likely to succeed before clinical trials. Researchers now have access to technologies that were unimaginable mere decades…...

5+ day, 3+ hour ago   (367+ words) A preclinical study published ha demonstrated how AI-assisted screening can unlock challenging cancer targets, with Mayo Clinic researchers identifying a GIPC1 inhibitor that slows tumour growth and potentiates gemcitabine activity in pancreatic cancer models. Researchers at Mayo Clinic have used artificial…...

5+ day, 23+ hour ago   (436+ words) Insilico Medicine has nominated an artificial intelligence-designed drug candidate for the potential treatment of several inflammatory and degenerative eye diseases including dry age-related macular degeneration (dry AMD), uveitis and dry eye disease. The company said ISM9077 had been selected as a…...