20+ hour, 19+ min ago  (273+ words) Research has failed to demonstrate that depression is caused by a deficit in central serotonin activity. Umbrella reviews show no consistent association between serotonin markers and major depressive disorder (MDD), and routine clinical practice does not measure serotonin before treatment. Selective…...

20+ hour, 19+ min ago  (230+ words) Background: The COVID-19 pandemic has had devastating direct impacts on health and has also contributed indirectly to a wide array of socioeconomic issues. In the United States (US), these impacts have been shown to be particularly pronounced among racial and…...

20+ hour, 19+ min ago  (293+ words) In contrast to the well-studied gonadotoxicity of traditional chemotherapy, data on the long-term effects of newer targeted molecular therapies on human ovarian reserves and fertility remain scarce. Here, we report the effect of osimertinib on ovarian reserve. Osimertinib is a…...

20+ hour, 19+ min ago  (160+ words) Self-inflicted oral injuries in children with neurological disorders represent a significant clinical concern due to their multifactorial impact on oral and systemic health. Neurological disorders, such as febrile infection-related epilepsy syndrome (FIRES) and glutaric aciduria type I, may cause dystonia,…...

20+ hour, 19+ min ago  (313+ words) Sepsis is a major cause of morbidity and mortality worldwide. Type 2 diabetes mellitus (T2 DM) is common among adults with infection and has been proposed as a potential modifier of sepsis outcomes. This systematic review and meta-analysis aimed to evaluate the association…...

20+ hour, 19+ min ago  (432+ words) Background Hemoglobinopathies are inherited disorders of hemoglobin synthesis and structure that continue to impose a significant health burden, particularly in the Indian subcontinent, where genetic diversity, endogamy, and consanguinity contribute to their high prevalence. Double heterozygous hemoglobinopathies show considerable clinical…...

20+ hour, 19+ min ago  (170+ words) The traditional approach to breast cancer control in Sub-Saharan Africa and East Africa has long been hindered by a reactive healthcare model that prioritizes symptomatic management over early, risk-stratified interventions. Drawing upon a multi-year research program conducted in Kenya that…...

20+ hour, 19+ min ago  (155+ words) Isolated finger compartment syndrome is a rare disorder and is sparsely recorded in the literature. Fascial compartment pressure builds up, reducing perfusion to the finger and potentially leading to irremediable injury. We present a case of a man with severe…...

20+ hour, 19+ min ago  (264+ words) Thioredoxin-related transmembrane protein 2 (TMX2)-related neurodevelopmental disorder (OMIM #618730) is an exceedingly rare autosomal recessive condition caused by biallelic pathogenic variants in TMX2, a gene encoding an endoplasmic reticulum (ER)-resident oxidoreductase involved in neuronal survival and cortical development. The condition is characterized…...

20+ hour, 19+ min ago  (267+ words) Background Angiogenesis is an important biological event in periodontal regeneration, as early vascular support is necessary for oxygen delivery, nutrient transport, and tissue healing. Guided tissue regeneration (GTR) membranes may influence this vascular response depending on their material properties. Aim…...