4+ hour, 43+ min ago  (271+ words) New modeling study shows curative treatments may be viable in low-income settings if costs are scaled and societal benefits included Gene therapy for sickle cell disease (SCD) could be cost-effective in Uganda " but only if prices are dramatically reduced and…...

1+ day, 1+ hour ago  (187+ words) A new genome-editing strategy could sidestep one of the field's biggest bottlenecks: the immune response triggered by double-stranded DNA (ds DNA). Researchers have developed "INSTALL," a system that pairs recombinases with circular single-stranded DNA (css DNA) donors to enable kilobase-scale…...

2+ day, 3+ hour ago  (163+ words) New Eveo system is designed to raise CAR-T output, cut manufacturing costs, and ease cleanroom bottlenecks Sartorius plans to begin taking orders for the Eveo Cell Therapy Platform in September 2026, with first deliveries expected in 2027. Elevate Bio, which helped test…...

2+ day, 3+ hour ago  (161+ words) Study reveals Fc fragment of antibody is essential for activating microglia to clear amyloid plaques By pinpointing the mechanism behind one of the field's most closely watched therapies, the work provides a clearer blueprint for Alzheimer's drug development " shifting the…...

3+ day, 6+ hour ago  (888+ words) Why vascularized tissues are gaining traction In this Q&A, Vox Cell's Graham Craig explores why human-relevant, vascularized tissue models are reshaping preclinical development " and how they could redefine the future of drug testing. In recent years, we've seen a…...

3+ day, 1+ hour ago  (81+ words) Review charts rise of language models, Alpha Fold, and generative AI in engineering next-generation therapeutics With new cases of avian influenza appearing, what does this mean for global health and what are drug developers doing about it? Can phage endolysins…...

3+ day, 6+ hour ago  (241+ words) Engineered immune cells clear amyloid and improve brain health in mice, offering a new direction for neurodegenerative therapy CAR-T therapy, best known for fighting blood cancers, is now being repurposed for brain disease. Researchers at Washington University in St. Louis…...

3+ day, 3+ hour ago  (122+ words) The overall message is clear: monoclonal antibodies are no longer limited by therapeutic promise, but by the difficulty of making them reliably, affordably, and at scale. As demand continues to grow, the future of the field will depend not only…...

6+ day, 6+ hour ago  (166+ words) New review maps how engineered regulatory T cells could calm brain inflammation in Alzheimer's, Parkinson's, ALS, and multiple sclerosis CAR T cells have already reshaped cancer treatment. Now, a new review argues that their immunosuppressive cousins " CAR Tregs " could open…...

1+ week, 5+ hour ago  (159+ words) Importantly, the system also worked in biofilms " dense, surface-bound bacterial communities that are notoriously difficult to eliminate and are implicated in many chronic infections. "The biofilm context for combating antibiotic resistance is particularly important," Bier noted, highlighting one of the…...