4+ day, 9+ hour ago  (275+ words) A total of 2726 participants with ADHD and 16, 299 control individuals were included for analysis from CAG at CHOP. The age range for both cohorts was between 3 and 21 years, with a mean age of 6 years. In the validation cohort, the genetic risk…...

4+ day, 9+ hour ago  (344+ words) An earlier childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) is associated with better educational outcomes, and a late diagnosis toward the end of mandatory education may lead to a higher risk for dropout and lower grade point average (GPA) scores,…...

2+ day, 13+ hour ago  (231+ words) Online dating has become increasingly popular, especially among younger individuals, even children. Previous studies have investigated the relationship between online dating and mental health among adults, but few studies have involved individuals younger than 18 years of age. Researchers conducted a…...

1+ mon, 1+ week ago  (268+ words) The Food and Drug Administration (FDA) is encouraging manufacturers of testosterone replacement therapy products to pursue a new indication: treating low libido in men with idiopathic hypogonadism. Testosterone replacement therapy (TRT) is currently available in multiple formulations, including oral, topical,…...

1+ mon, 1+ week ago  (313+ words) Opioid analgesics reduce pain in acute conditions but showed variable efficacy across clinical settings and timepoints and evidence of increased adverse events. The study findings of systematic reviews and meta-analyses were published in Drugs journal. Although opioids are important for…...

3+ week, 4+ day ago  (195+ words) After systematic screening, 5648 patients with schizophrenia and 23, 636 control individuals were included for analysis. Most studies had a NOS score between 5 and 9, or moderate to high quality. The primary outcomes were frontal QRS-T angle, Tpeak-Tend (Tp-e) interval, and Tp-e/QT ratio,…...

3+ week, 5+ day ago  (288+ words) Otarmeni is an adeno-associated virus vector-based gene therapy designed to deliver a working copy of the OTOF gene primarily in inner hair cells via an infusion into the cochlea. By facilitating the production of functional otoferlin protein, Otarmeni is expected…...

3+ week, 5+ day ago  (293+ words) Amyloid-beta-targeted monoclonal antibodies had negligible effects for adults with mild cognitive impairment or AD-related dementia. Health Day News " For adults with mild cognitive impairment (MCI) or mild dementia due to Alzheimer disease, amyloid-beta-targeted monoclonal antibodies have negligible or little effect, according…...

3+ week, 4+ day ago  (279+ words) Among older East Asian adult populations, genetic liability to long sleep duration and early chronotype is linked with lower baseline late-life cognitive performance, primarily reflective of baseline differences in cognitive status, but not with short-term cognitive decline. These study findings…...

3+ week, 4+ day ago  (258+ words) Researchers conducted a systematic review and meta-analysis to examine the prevalence and incidence of anxiety, insomnia, and depressive symptoms in women with postmenopausal and perimenopausal status. Depressive symptoms were common, with a pooled point prevalence of 30% in postmenopausal (95% CI, 27%-34%; n…...