1+ day, 7+ min ago  (666+ words) A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is associated with faster aging [1]. To address some of the knowledge…...

19+ hour, 44+ min ago  (1698+ words) The FDA views aging as an inevitability, not a medical target. However, with Life Biosciences moving the first cellular reprogramming therapy into human trials this year, things might be changing there. If this technique works in resetting the biological age…...

2+ day, 8+ min ago  (775+ words) The pro-Alzheimer's allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Scientists have long known that years before visible symptoms appear, the brain's hub…...

3+ day, 4+ min ago  (521+ words) Furthermore, post-operative delirium is linked to further permanent damage to already damaged brains [4]. Nearly two-thirds of people with existing mild cognitive impairment went on to develop full-blown Alzheimer's disease within three years of experiencing delirium after surgery [5]. This team noted…...

6+ day, 18+ min ago  (285+ words) Building on two previous deals between the companies, this new agreement is potentially worth up to $2. 75 billion and involves Lilly licensing assets from Insilico's pipeline. The companies have not publicly disclosed the exact number of licensed assets, the targets, or…...

1+ week, 5+ min ago  (262+ words) In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. These researchers have done previous work demonstrating that phosphoenolpyruvate carboxykinase 1 (Pck1) deficiency shortens the lifespan of…...

1+ week, 18+ hour ago  (464+ words) A recent study suggests that the transition of king penguins from the wild to a zoo environment, which resembles a sedentary, well-fed Western lifestyle, results in accelerated aging and changes in metabolic pathways [1]. "We wanted to investigate whether turning these…...

1+ week, 23+ hour ago  (1580+ words) For many hundreds of years, Easter has been associated with rebirth and rejuvenation. Let's see what's been done last month to rejuvenate animals and people. Support the Human Ageing Genomic Resources: Jo'o Pedro de Magalh'es has launched a fundraiser to…...

1+ week, 5+ day ago  (10+ words) Mitochondria Delivery Method Rescues Parkinson's in Mice'Lifespan Research Institute...

2+ week, 1+ day ago  (599+ words) A new study identified two polyunsaturated fatty acids, "-eleostearic acid ("-ESA) and "-ESA methyl ester ("-ESA-me), that showed senolytic activity in cell cultures and a mouse model[1]. The researchers began their study by using senescent cell cultures to screen fatty…...