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Multiancestry Risk Scores Improve Type 2 Diabetes Prediction
1+ week, 2+ day ago (442+ words) Validated, publicly available polygenic risk scores (PRSs) can improve risk stratification for type 2 diabetes (T2 D) onset and complication across diverse ancestries, according to study findings published in the Lancet Diabetes & Endocrinology. In this meta-analysis of genome-wide association studies (GWAS), researchers aimed…...
GLP-1 Lawsuits: An Update and What You Should Know as a Prescriber
3+ week, 2+ day ago (801+ words) The first glucagon-like peptide-1 (GLP-1) receptor agonist medication was approved by the US Food and Drug Administration (FDA) in 2005 for the treatment of type 2 diabetes. In 2014, the first GLP-1 specifically for chronic weight management was approved. But it was the…...
FDA Signals Support for TRT Label Expansion for Low Libido in Men
1+ mon, 1+ week ago (268+ words) The Food and Drug Administration (FDA) is encouraging manufacturers of testosterone replacement therapy products to pursue a new indication: treating low libido in men with idiopathic hypogonadism. Testosterone replacement therapy (TRT) is currently available in multiple formulations, including oral, topical,…...
CDC Report on COVID Vaccine Blocked From Publication
3+ week, 3+ day ago (22+ words) A federal report pointing out the benefits of COVID-19 vaccines may never be released, as it has been rejected from publication....
Obesity Treatment Response Linked to Reduced Risk in Children With MHO and MUO
1+ mon, 3+ day ago (302+ words) A reduction in body mass index z-score (BMI-z) of at least 0. 25 is associated with similar risk reductions for both metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) among children, according to study results published in JAMA Pediatrics. In this…...
Platinating Agents Increase Azoospermia Risk in Childhood Cancer Survivors
1+ mon, 1+ week ago (373+ words) Higher cumulative alkylating agent exposure is independently associated with impaired spermatogenesis among adult survivors of childhood cancer, whereas concomitant platinating agent therapy substantially increases the risk for azoospermia and oligospermia, according to results of a study published in Fertility and…...
Tirzepatide Improves HRQo L vs Dulaglutide in Patients With T2 D, ASCVD
1+ mon, 2+ day ago (204+ words) In this randomized, controlled, phase 3 trial, researchers aimed to examine HRQo L among people with T2 D and established ASCVD treated with tirzepatide compared with dulaglutide. A total of 13, 299 adults (mean age, 64. 1 years; T2 D duration, 14. 7 years; Hb A1c, 8. 4%; body mass index [BMI],…...
Short-Term GLP-1 RA Use Linked to Higher Risk for New-Onset Rheumatoid Arthritis
1+ mon, 3+ day ago (19+ words) Use of certain GLP-1 RAs is associated with a modestly increased risk for new-onset rheumatoid arthritis (RA)....
Noncardiometabolic Effects of GLP-1 RAs Show Low Evidence Certainty
3+ week, 6+ day ago (324+ words) The certainty and credibility of evidence relating glucagon-like peptide-1 receptor agonists (GLP-1 RAs) with noncardiometabolic effects is low, according to findings from an umbrella review published in JAMA Network Open. The metabolic and cardiovascular benefits of GLP-1 RAs are well-established....
Veligrotug Rapidly Reduces Proptosis in Active Thyroid Eye Disease
1+ mon, 2+ day ago (202+ words) Veligrotug produces rapid, substantial, and well-tolerated reductions in proptosis by week 15, according to study results presented at the American Association of Clinical Endocrinology (AACE) Annual Meeting held in Las Vegas, Nevada, from April 22 to 24, 2026. Proptosis was measured using Hertel exophthalmometry…...
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