1+ day, 18+ hour ago   (552+ words) New research shows that a viral polymerase inhibitor developed at Georgia State University, named GHP-88310, can block canine distemper virus transmission in ferrets under conditions designed to mimic real-world measles spread – which could inform new outbreak response strategies. A new…...

1+ day, 20+ hour ago   (408+ words) Researchers have used the GAGE-seq technique and an AI model called Hicformer to demonstrate that the three-dimensional folding of the genome is significantly disrupted in brain cells affected by Alzheimer’s disease – a finding that could help prioritise new targets for…...

2+ day, 17+ hour ago   (452+ words) Insilico Medicine has announced ISM9528, a potential first-in-class non-opioid therapy for chronic pain, has demonstrated superior preclinical efficacy to morphine and pregabalin and a favourable safety profile. Insilico used its PandaOmics artificial intelligence platform to identify and prioritise a previously unrecognised…...

2+ day, 21+ hour ago   (260+ words) ELRIG has expanded its Scientific Advisory Board with two senior appointments, drawing on more than 50 years of combined drug discovery experience to guide the organisation’s strategic direction and conference programming. ELRIG has strengthened its Scientific Advisory Board (SAB) with the…...

3+ day, 17+ min ago   (1098+ words) Drug developers have generated decades of toxicology data and insights, but much of it remains underused. Laura Lotfi of Charles River Laboratories discusses how Virtual Control Groups and AI could help put that information to work. Safety assessment is a…...

3+ day, 18+ hour ago   (550+ words) A new preclinical study has shown that Setanaxib, an inhibitor of the oxidative stress enzymes NOX1 and NOX4, preserved cardiac function and reduced fibrosis in two models of Duchenne muscular dystrophy. Researchers at the University of South Florida (USF) Health Morsani College…...

3+ day, 20+ hour ago   (371+ words) Whether you source, purchase or work with human biospecimens, understanding today’s ethical and regulatory expectations is essential. Join this webinar to explore informed consent, privacy and the principles that support responsible research. In this webinar, BioIVT’s Compliance & Regulatory Affairs (C…...

3+ day, 21+ hour ago   (287+ words) A novel bispecific T cell engager combining precision antibody engineering with an in vivo DNA delivery platform has shown improved tumour-killing activity and extended half-life in preclinical ovarian cancer studies. Scientists at The Wistar Institute have developed a new form…...

4+ day, 17+ hour ago   (563+ words) Researchers have developed a library of 220 patient-derived tumour organoids spanning 15 cancer types, demonstrating their long-term fidelity as preclinical models and their capacity to replicate the tumour immune microenvironment. Significant developments in the creation of new patient-derived tumour organoids could lead…...

4+ day, 21+ hour ago   (1107+ words) Can AI help researchers identify better drug candidates before they reach the laboratory? New research in opioid use disorder (OUD) suggests that combining human-derived biology with AI could improve how therapeutic targets and drug candidates are selected. Choosing the right…...