News
DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis - Nature Communications
6+ hour, 22+ min ago (1688+ words) For metabolic experiments, fresh CRC samples were collected and snap frozen using liquid nitrogen. Patient tissue microarray (TMA) slides (CO1502) comprising colorectal cancer specimens (N=75) with two cores for each patient were procured from Tissuearray. com LLC. For performing the Gene Set…...
Cumberland Village officially certified by American Heart Assoc.
15+ hour, 46+ min ago (157+ words) WLAF Chamber of Commerce & Tourism ribbon cutting marks the occasion LAFOLLETTE, TN (WLAF)- "Congratulations to My Genesis Health Care, Cumberland Village, on your Chamber Ribbon Cutting and your Official Certification by the American Heart Association," said Missy Tackett, Executive Director…...
Recency of practice and CDP changes
8+ hour, 36+ min ago (263+ words) THE Australian Health Practitioner Regulation Agency (Ahpra) and National Boards are consulting on proposed changes to recency of practice and continuing professional development (CPD) registration standards, with pharmacists invited to have their say. Key proposed changes around recency of practice…...
USP22 deubiquitinates and stabilizes ERK1/2 to promote colorectal cancer progression - Acta Pharmacologica Sinica
6+ hour, 22+ min ago (869+ words) Acta Pharmacologica Sinica (2026) Cite this article All the data generated or analyzed during this study are available from the corresponding author upon reasonable request. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer…...
Frontiers | Effects of SOX10 on the proliferative, invasive, migratory, and epithelial'mesenchymal transition abilities of triple-negative breast cancer cells
3+ hour, 11+ min ago (270+ words) Targeting the Wnt/-catenin Signaling Pathway in Cancer Vol II Front. Oncol. , 18 May 2026 SOX10 overexpression significantly promoted proliferation, migration, and invasion in both TNBC cell lines, while SOX10 knockdown markedly inhibited these abilities (all P SOX10 promotes malignant biological behaviors in TNBC cells…...
Greycoat Research Ushers in the Era of "Personalized Precision Nutrition" for Feline Kidney Disease
10+ hour, 20+ min ago (245+ words) Greycoat Research, an R&D-based feline healthcare specialist, announced on the 18th that it is expanding its new business by launching 'Personalized Precision Nutrition' management services that reflect the unique genetic characteristics of individual cats. Yun Jeong-eun, CEO of Greycoat Research,…...
VCPIP1 drives diabetic cardiomyopathy by deubiquitinating AMPK1 and preventing AMPK- subunit assembly in cardiomyocytes | Signal Transduction and Targeted Therapy
6+ hour, 22+ min ago (1597+ words) HEK293 T, AC16, and H9 C2 cell lines were procured from the Shanghai Institute of Biochemistry and Cell Biology (Shanghai, China) and subsequently cultured in DMEM containing 10% FBS under standard conditions. To quantify cardiomyocyte hypertrophy, paraffin-embedded heart tissue sections were stained using a WGA…...
Targeting EHMT2 overcomes 5-fluorouracil resistance in colorectal cancer by modulating cell cycle and apoptosis - Signal Transduction and Targeted Therapy
5+ hour, 43+ min ago (1251+ words) The human colorectal cancer (CRC) cell lines HCT116 and HT29 were cultured in Roswell Park Memorial Institute (RPMI) medium supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin. To induce 5fluorouracil (5-FU) resistance, the two CRC cell lines were exposed to increasing concentrations of…...
Derry fire officials tout AED loaner program
10+ hour, 17+ min ago (544+ words) Derry Fire Department/EMS Director Capt. Edward King shows some of the AEDs and supplies at the fire station on Rockingham Road. The Derry department has a loaner program that offers free AED devices and training to the community. The…...
Frontiers | Single-cell RNA sequencing unveils macrophage heterogeneity and cell-cell interactions in hepatocellular carcinoma progression
10+ hour, 22+ min ago (309+ words) Front. Genet. , 18 May 2026 Sec. Human and Medical Genomics 1. Department of Liver Diseases, Shu Guang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China 2. Department of TCM Gynecology, The International Peace Maternity and Child Health Hospital, School of Medicine,…...