6+ hour, 40+ min ago  (235+ words) Neuronal activity regulates glial physiology, but the effects of prolonged synaptic silencing in mature circuits are unclear. Using Rbp4-Cre-mediated Snap25 deletion to block neurotransmitter release in subsets of cortical layer 5 neurons and dentate gyrus granule cells, we examined glial responses across…...

2+ day, 1+ hour ago  (237+ words) New research led by Prof Edward Avezov (UK DRI at Cambridge) reveals how the architecture of the cell's transport network, the endoplasmic reticulum, can go awry and lead to problems with signalling in the brain cell in conditions like Alzheimer's....

2+ week, 2+ day ago  (513+ words) In a new paper, researchers at the UK DRI at Imperial published the first evidence that stimulating the hippocampus " the brain's memory centre " using a special type of non-invasive stimulation helps it grow new neurons. The research is published in…...

3+ week, 6+ day ago  (174+ words) What was the challenge? What did the team do and what did they find?" The team showed that by including this humanised amyloid beta protein sequence, they were able to reproduce features of early Alzheimer's in the mice. For example,…...

1+ mon, 4+ day ago  (418+ words) The aim of this study is to assess the levels of meprin-, an alternative -secretase in the brain and cerebrospinal fluid of subjects suffering Alzheimer's disease. The full-length zymogen and the active species of meprin- were characterized by immunoblotting and…...

1+ mon, 6+ day ago  (116+ words) What was the challenge? However, it has been unclear exactly which ultrasound parameters should be used to achieve this. Researchers have undertaken studies at a range of frequencies, with different pressures and treatment times, making it difficult to compare results…...

1+ mon, 1+ week ago  (47+ words) UK DRI Correction: Comorbidities predict institutionalization and mortality in biomarker-confirmed alzheimer's disease Alzheimers Res Ther. 2026 May 20; 18(1): 117. doi: 10. 1186/s13195-026-02072-x. Pioneering the development of fluid biomarkers for dementia...

1+ mon, 2+ week ago  (203+ words) What was the challenge? Circadian clocks in cells coordinate daily rhythms in gene expression, physiology, and behaviour. In mammals, these rhythms depend on an area of the brain called the suprachiasmatic nucleus (SCN), a small region in the hypothalamus that…...

1+ mon, 3+ week ago  (381+ words) Alterations in plasma sphingomyelin (SM) levels have been reported in Alzheimer's disease (AD), pointing to disturbances in lipid metabolism that may contribute to disease pathogenesis. Neuronal damage in early AD triggers tau release into central and peripheral systems. Despite influence…...

1+ mon, 3+ week ago  (222+ words) INTRODUCTION: Only 6% of UK memory services meet Alzheimer's disease (AD) biomarker access guidelines, limiting psychiatrists' experience. Emerging AD blood biomarker (BBM) tests will potentially expand access. Exploring implementation barriers and enablers a priori can inform rollout strategies. This study examined…...