News
JCI -Welcome
2+ day, 16+ hour ago (282+ words) Welcome JCI. org Crimean-Congo hemorrhagic fever virus glycoprotein 38 in mice is targeted with human antibodies In this episode, James Crowe describes how these studies support the development of CCHFV countermeasures to induce protection against GP38 in vivo. Human antibody targeting Crimean-Congo…...
Wdr26 insufficiency causes Skraban-Deardorff syndrome'like neurodevelopmental deficits in mice
2+ day, 16+ hour ago (52+ words) JCI. org Wdr26 insufficiency causes Skraban-Deardorff syndrome'like neurodevelopmental deficits in mice Xingyun Xu, Yaohui Zhou, Shiyao Xu, Hongjie Zhou, Xuexia Lin, Yuhao Luo, Yu Xu, Zhigang Miao, Wei Ge, Hao Yang, Xingshun Xu Wdr26+/' mice are established and verified....
Targeting RANKL-independent osteoclastogenesis overcomes denosumab resistance in models of ER
2+ day, 16+ hour ago (658+ words) Find articles by Duan, Z. in: Pub Med | Google Scholar Find articles by Luo, J. in: Pub Med | Google Scholar Find articles by Zhang, W. in: Pub Med | Google Scholar Find articles by Xia, Y. in: Pub Med | Google Scholar Find articles by Zeng,…...
Progressive cardiac phenotypes and reduced reversibility from long-term CUG
1+ week, 2+ day ago (261+ words) JCI. org Progressive cardiac phenotypes and reduced reversibility from long-term CUGexp RNA expression in a DM1 mouse model Myotonic dystrophy type 1 (DM1) is caused by an expanded CTG repeat in the DMPK gene, resulting in mutant transcripts that form expanded CUG (CUGexp)…...
JCI Insight - Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway
2+ week, 1+ day ago (316+ words) JCI. org Recurrent moderate hypoglycemia accelerates the progression of Alzheimer's disease through impairment of the TRPC6/GLUT3 pathway Currently, the most effective strategy for dealing with Alzheimer's disease (AD) is delaying the onset of dementia. Severe hypoglycemia is strongly associated with dementia;…...
Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases
1+ mon, 2+ week ago (90+ words) JCI. org Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases Bingyu Yan, Jinwoo Lee, Suhas Srinivasan, Pedro Ambriz, Quanming Shi, Diana R. Dou, Srijana Davuluri, Swarna Nandyala, Adrianne Woods, Gwendolyn Leatherman, Yanding Zhao, Roman…...
Cotargeting DNA topoisomerase II enhances efficacy of RAS-targeted therapy in KRAS-mutant cancer models
3+ mon, 2+ day ago (803+ words) Find articles by Xu, R. in: Pub Med | Google Scholar Find articles by Wang, D. in: Pub Med | Google Scholar Find articles by Ma, G. in: Pub Med | Google Scholar Find articles by Yuan, X. in: Pub Med | Google Scholar Find articles by Chu,…...