5+ day, 8+ hour ago   (833+ words) Robert Darnell has spent 30 years chasing an unexpected thread from rare brain diseases to the basic mechanisms of how cells read their DNA. (Credit: Lori Chertoff) Darnell wanted to know why. What connects all of it is not only a…...

1+ week, 3+ day ago   (476+ words) The Rockefeller University A few minutes of sprinting could make a bigger impact than 90 minutes of moderate running Brief bursts of intense exercise trigger a molecular response linked to a lower risk of cardiovascular and metabolic disease and that are…...

1+ week, 4+ day ago   (361+ words) “We learned that if you’re writing guidelines for clinical care, it’s better to base them on each individual’s multimorbidity rather than on chronological age alone,” says Cohen. “That’s a categorical shift.” Tobin adds, “This new understanding of multiple comorbidity is…...

1+ week, 6+ day ago   (296+ words) The Darst lab has shown how two classes of antibiotics (pictured in green) jam the enzyme responsible for the transcription of DNA to RNA. They do this by locking a key structural component in place. (courtesy of Darst lab) “It’s…...

2+ week, 3+ day ago   (267+ words) Rockefeller’s Jarvis lab has assembled the first fully phased, diploid telomere-to-telomere genome of a songbird, which constitutes the most complete and accurate bird genome to date. (Figure courtesy of Jarvis lab, illustration: b.illustrations) The zebra finch is one of…...

3+ week, 2+ day ago   (175+ words) Rockefeller’s Birsoy and Vinogradova labs teamed up to study how cancer cells rewire their metabolism, and how these changes could be targeted therapeutically. The right tools for the job Collaborating was a no-brainer for Birsoy and Vinogradova, as their separate…...

3+ week, 3+ day ago   (572+ words) Histological image of lung tissue from a SARS-CoV-2–infected mouse fed an arginine-restricted diet. (Courtesy of Tavazoie lab) The amino acid arginine helps to keep the human body humming, most notably by synthesizing proteins that carry out a range of…...

3+ week, 5+ day ago   (632+ words) Elizabeth Campbell studies the molecular machinery that all living cells use to read and transcribe their genetic instructions. Her lab is finding new ways to block this critical machinery in bacteria and viruses. (Credit: Lori Chertoff) Every living cell, from…...

1+ mon, 9+ hour ago   (207+ words) FlatMux captures electrical activity optically from nearly 200 genetically defined neurons across new depths in brain circuits, revealing how signals flow, cells connect, and computations emerge in a living mouse brain. (Image courtesy of the Vaziri lab) The brain is a…...

1+ mon, 1+ day ago   (402+ words) Video footage from software that tracks the trajectories of fruit flies as they weave in and out of an odor plume. The Ruta lab’s latest study reveals how flies store a memory of how to relocate a scent, even after…...