19+ hour, 25+ min ago  (251+ words) Immune checkpoint inhibitors (ICIs) have altered cancer care, yet many patients experience limited or short-lived responses. A new comparative effectiveness study published in JAMA Network Open suggests that adding a proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) may improve outcomes in…...

1+ day, 11+ hour ago  (276+ words) Newborns exposed to opioids antenatally showed region-specific impairments in cerebral cortical folding compared with nonexposed newborns, according to findings from a cohort study published in JAMA Network Open. "This study provides important new evidence that differences in brain development associated…...

1+ day, 10+ hour ago  (219+ words) The authors noted that assessment of RV dysfunction among ED patients with PE facilitates risk stratification. "Patients with PE and associated right ventricular dysfunction have higher mortality, as well as increased risk of shock, respiratory failure, and PE recurrence," wrote…...

1+ day, 14+ hour ago  (378+ words) Q&A: How Chemoimmunotherapy Has Impacted Survival in Veterans With ES-SCLC, Brain Metastases Physician's Weekly spoke with lead author Jason Cham, MD, of Columbia University, about how to interpret the findings and how clinicians can better communicate clinical trial information with…...

1+ day, 13+ hour ago  (60+ words) Physician's Weekly Integrating Women's Cancer Screening Guidance Into Clinical Practice To provide a comprehensive update on women's preventive care, researchers in Cureus synthesized information from international guidelines and consensus statements published in the last 10 years. Sleep Management & Specialist Referrals: Where…...

2+ day, 18+ hour ago  (155+ words) Circulating inflammatory mediators link injury across systems. Inflammatory cytokines such as IL-6, TNF, and CXCL1 act as systemic messengers, circulating injury between organs. Kidney injury can increase pulmonary neutrophil infiltration and vascular leakage, while anti-inflammatory IL-10 attempts, often not sufficiently, to dampen this…...

2+ day, 13+ hour ago  (106+ words) The findings stemmed from a population-based cohort study of more than 1 million near-term and full-term children without major congenital anomalies who were born in Denmark between 2004 and 2022 and followed until 2025. Researchers were interested in associations between early-onset neonatal infections, defined…...

2+ day, 15+ hour ago  (196+ words) Given the rapidly expanding therapeutic use of these agents and emerging preclinical data suggesting immunomodulatory effects, we examined whether GLP-1 RA exposure following cancer diagnosis was associated with altered risk of progression to metastatic disease," explained the researchers of the…...

5+ day, 18+ hour ago  (638+ words) Learning Without Harm: The Ethics of "Fail Fast" in Medicine In biotech, failure fuels progress. In medicine, it signals harm. But in clinical medicine, failure does not resolve into a clean data point. It lingers. It carries weight. It has…...

1+ week, 21+ hour ago  (142+ words) Results revealed that the primary composite outcome occurred among 40. 8% of the vitamin C cohort compared with 29. 7% in the placebo cohort (adjusted risk ratio [RR], 1. 28; P=0. 06). Although narrowly missing conventional statistical significance, the result crossed the trial's predefined futility/harm threshold,…...