4+ day, 7+ hour ago  (282+ words) Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. "Instead of targeting one downstream molecule at a time, we aimed to retune the fat's entire gene activity program," said UZH…...

5+ day, 6+ hour ago  (238+ words) In Aging Cell, researchers have described the way that antioxidants work against senescence in muscle cells by altering m TOR signaling. [1] Liu, G. Y. , & Sabatini, D. M. (2020). m TOR at the nexus of nutrition, growth, ageing and disease. Nature reviews Molecular cell biology, 21(4), 183-203. [2] Tang,…...

1+ week, 7+ hour ago  (592+ words) In a new study, muscle-targeted viral-vector-based delivery of the protein FGF21 significantly increased median lifespan in male mice and improved many healthspan markers [1]. Metabolic dysregulation is a core cause of aging [2]. As animals (and people) age, they tend to gain fat,…...

1+ week, 1+ day ago  (600+ words) A team of reviewers has taken a look at the relationship between cancer, cellular senescence, and vascular overgrowth and published this information in Aging Cell. The SASP factors involved in angiogenesis have been identified. Specifically, the well-known inflammatory factor NF-B…...

1+ week, 5+ day ago  (426+ words) Scientists have "faked" sleep in mice by artificially creating the on/off neuronal firing pattern similar to that seen in non-REM sleep. This produced sleep-like effects, including improved learning memory [1]. Getting proper amounts and quality of sleep is one of…...

2+ week, 3+ hour ago  (374+ words) In Aging Cell, researchers have described how a strain of Lactobacillus gut bacteria sends chemical signals that enter the bloodstream and decrease fibrosis in the lungs. This study, however, focuses on a different condition: pulmonary fibrosis. Fibrosis is fairly well-explained…...

2+ week, 1+ day ago  (604+ words) Researchers have explained how a protein found in both yeast and humans facilitates the destruction of the core protein responsible for Parkinson's disease. Proteins are often modified after they are created by cells, and "-syn is susceptible to being phosphorylated…...

2+ week, 5+ day ago  (509+ words) Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing mi R-330, a key regulator in cartilage and bone cells. It has been long-held conventional wisdom that a lifetime of heavy physical labor leads to…...

2+ week, 6+ day ago  (251+ words) Evipedia was built to solve a problem familiar to anyone navigating the longevity field: the literature is vast, fragmented, fast-moving, and full of marketing posing as evidence. The encyclopedia distills the current state of evidence for each intervention into a…...

3+ week, 8+ hour ago  (1534+ words) The longevity field remains small and starved for resources, especially the subfield devoted to the fundamental biology of aging, despite near-universal agreement that solving aging requires understanding it first. With VCs looking for clinical successes and state funding drying up…...