20+ hour, 20+ min ago  (501+ words) Researchers at RCSI University of Medicine and Health Sciences have reported the first preclinical evidence for an m RNA vaccine against neuroblastoma, using targeted nanoparticle delivery to train the immune system against cancer cells. Researchers at RCSI University of Medicine…...

1+ day, 1+ hour ago  (184+ words) As drug developers pursue increasingly complex therapies, traditional bioanalytical approaches are being put to the test. How is the field adapting to meet these new demands? As pharmaceutical research and development has evolved, however, the scope and demands placed on…...

5+ day, 19+ hour ago  (326+ words) The partnership will focus on identifying novel antibody therapies designed to overcome some of the most significant limitations associated with current immunotherapies, particularly on-target, off-tumour toxicities that can lead to serious side effects in patients. Under the agreement, the companies…...

5+ day, 23+ hour ago  (540+ words) Protein nanocages have been growing as a research focus in recent years due to their potential as a platform for next-generation drug delivery systems. These hollow structures, which measure only nanometres in size, are formed when multiple proteins spontaneously bind…...

1+ week, 19+ hour ago  (641+ words) Researchers at Purdue University have developed a next-generation technology platform that could improve one of the most difficult stages of cancer drug discovery by rapidly identifying compounds with the potential to become new treatments. The automated ultrahigh-throughput platform, created by…...

1+ week, 22+ hour ago  (334+ words) Researchers from the Terasaki Institute for Biomedical Innovation and leading experts in glioma biology, neuro-oncology and stem cell biology have published a major review outlining a new framework for glioma organoid research. The paper, published in the journal Neuro-Oncology, examines…...

1+ week, 1+ day ago  (457+ words) Indiana University researchers are launching a five-year, $6 million initiative to harness artificial intelligence and machine learning for Alzheimer's drug discovery." A new $6 million research initiative is bringing together experts from Indiana University to develop artificial intelligence tools that could speed…...

1+ week, 1+ day ago  (459+ words) A new study from the Mayo Clinic has discovered an alternative pathway for kidney water retention that operates independently of vasopressin, potentially enabling more tolerable treatments for polycystic kidney disease." Researchers at Mayo Clinic have identified a previously unknown mechanism…...

1+ week, 3+ day ago  (626+ words) Static cultures may not tell the whole story when it comes to immunotherapy performance. Results from the Mera" flow-based human tissue model show stronger T-cell activity and cytokine responses under physiological flow, highlighting the role of dynamic immune'tumour interactions in…...

1+ week, 2+ day ago  (465+ words) Scientists at the IBS Center for Synaptic Brain Dysfunctions have demonstrated that inhibiting the glycine transporter SLC6 A20 can restore NMDA receptor activity in autism models." A team of scientists has identified a new therapeutic strategy for autism spectrum disorder (ASD) by…...