2+ hour, 56+ min ago  (315+ words) Background Fentanyl overdose in humans produces two life-threatening effects: central "-opioid receptor (MOR)-mediated hypoventilation and generalized muscle rigidity that further impairs ventilation. Naloxone, the current standard of care, reverses both effects via competitive antagonism at MOR; however, its clinical…...

2+ hour, 36+ min ago  (247+ words) Primary localized cutaneous amyloidosis (PLCA) is characterized by amyloid deposition limited to the skin and is subdivided into macular, lichenoid, and nodular variants. Primary cutaneous nodular amyloidosis (PCNA) is the rarest subtype and typically presents as waxy, firm nodules or…...

1+ hour, 13+ min ago  (263+ words) Introduction When comparing surgical outcomes for individual physicians, it is important to note the multifactorial element of socioeconomic status (SES) in recovery complications. Area-based measures of SES, like residential zip codes, are often used in risk-adjustment models. In this study,…...

5+ hour, 41+ min ago  (202+ words) Nivolumab, a programmed death-1 (PD-1) immune checkpoint inhibitor (ICI), improves outcomes in advanced renal cell carcinoma (RCC) by enhancing antitumor T-cell activity. Immune activation may result in immune-related adverse events, including endocrine dysfunction. Thyroid abnormalities are commonly observed, whereas adrenal insufficiency…...

9+ hour, 21+ min ago  (158+ words) Adequate attached gingiva is cardinal for periodontal health maintenance. It helps to prevent apical migration of the gingival margin and serves as a stable barrier against plaque accumulation and plaque-induced inflammation of the gingiva. To increase attached gingiva, many techniques…...

2+ hour, 56+ min ago  (221+ words) Introduction Iris fabrication is central to ocular prosthesis aesthetics, yet comparative evidence on oil'painting versus photo'printing under environmental stressors remains limited. This study evaluated colour stability, dimensional stability and objective acceptability of conventionally oil'painted and photo'printed irises in ocular prostheses…...

5+ hour, 6+ min ago  (155+ words) Perforated appendicitis can be associated with a variety of postoperative complications, most notably abscess and wound infection. Perforation of the appendix can cause regional inflammation that affects neighboring tissues and organs. Occasionally, unexpected additional pathology emerges in the postoperative setting....

5+ hour, 36+ min ago  (178+ words) Penetrating aortic ulcer (PAU) is a rare but highly lethal manifestation of acute aortic syndrome (AAS), most commonly seen in elderly patients with advanced atherosclerosis. Ascending aortic involvement is particularly uncommon but carries a high risk of rupture, hemopericardium, and…...

5+ hour, 36+ min ago  (253+ words) This systematic review aims to compare the efficacy of hypoglossal nerve stimulation (HNS) versus continuous positive airway pressure (CPAP) for patients with obstructive sleep apnea (OSA). A literature search was performed in Pub Med and the Cochrane Library using keywords…...

9+ hour, 22+ min ago  (242+ words) Liver cirrhosis complicated by type 2 diabetes mellitus (T2 DM) is associated with significantly increased risks of hepatic decompensation, infection, and mortality. The optimal antidiabetic strategy in this population remains poorly defined, with limited evidence directly comparing available agents. This meta-analysis compared the…...