11+ hour, 34+ min ago   (1579+ words) The 2026 Lasker Award winners advanced understanding and treatment of narcolepsy, hemophilia, and Parkinson's disease. In August, the FDA approved Takeda’s Orzeyful (oveporexton) tablets to treat narcolepsy type 1 (NT1) in adults. The drug is the first approved treatment for NT1 designed to address…...

19+ hour, 3+ min ago   (1587+ words) Independent research identifies PLA2G2D as a potential new target for treating cancers resistant to PD-1 inhibitors. Two independent research teams have discovered the same previously overlooked immune checkpoint that may help explain why some cancers resist immunotherapy. In a study published…...

19+ hour, 27+ min ago   (242+ words) Drug Discovery News Efficient slide-based tissue imaging: from whole-slide context to cellular detail See how advanced slide-based imaging connects tissue architecture with cellular detail across fluorescent and histological samples. Tissue researchers often need to connect whole-slide tissue architecture with cellular-level…...

1+ day, 9+ hour ago   (1255+ words) The researchers found that the new cell type (pink) invites regulatory T cells (green) to the border of lung tumors for protection from the immune system. Credit: Olivia Ringham at Columbia University Vagelos College of Physicians and Surgeons Imagine finding…...

1+ day, 21+ hour ago   (986+ words) Personalized mRNA cancer vaccines require manufacturing a distinct batch for every patient, a shift that is pushing drugmakers toward automated, small-batch production systems. Personalized mRNA cancer vaccines just cleared their biggest scientific hurdle. Recent Phase 3 data in melanoma showed the…...

2+ day, 21+ hour ago   (1533+ words) New genetic targets point toward future OCD and tic disorder treatments. For more than two decades, researchers have been collecting DNA from families affected by obsessive-compulsive disorder (OCD) and chronic tic disorders (CTDs). When they began, the technologies needed to…...

1+ week, 20+ hour ago   (1540+ words) Credit: University of Rochester Medicine The findings from the 3D retina model also helped the team identify and test a new treatment to target the RPE cells in the organoid and a large animal model, which could lead to much better…...

1+ week, 2+ day ago   (1256+ words) Neuro-Innovators is testing a combination of FDA-approved drugs to promote neuroplasticity after stroke. Neuro-Innovators is taking a multi-pathway approach to that challenge. Rather than searching for a single new molecule, the company is combining existing FDA-approved drugs in an effort…...

2+ week, 21+ hour ago   (1585+ words) Hepatitis B causes damage to the liver and affects hundreds of millions of people worldwide. The hepatitis B virus (HBV) vaccine is up to 90 percent effective at preventing HBV when given within 24 hours after birth. But for the hundreds of…...

2+ week, 1+ day ago   (1314+ words) The research team discovered why the drug acts differently from others in its class. Losing weight can happen via two paths: eating less, or spending more energy. Today’s blockbuster GLP-1 drugs are well-known for their ability to help people eat…...