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Mayo Clinic researchers develop more efficient system to reprogram stem cells

https://www.eurekalert.org/pub_releases/2019-02/mc-mcr021219.php
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Feb 12, 2019 12:00 AM 2+ mon ago

Mayo Clinic researchers develop more efficient system to reprogram stem cells

Mayo Clinic researchers develop more efficient system to reprogram stem cells

ROCHESTER, Minn. -- Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails. Mayo researchers now report that using the measles virus vector; they've trimmed that multi-vector process with four reprogramming factors down to a single "one cycle" vector process. They say the process is safe, stable, faster and usable for clinical translation. The findings appear in the journal Gene Therapy.

"If we're going to successfully use reprogrammed stem cells to treat patients in the clinic, we need to ensure that they are safe and effective, that is, not prone to the risk of mutation and potential tumors," says Patricia Devaux, Ph.D., Mayo Clinic molecular scientist ...

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More efficient system to reprogram stem cells

sciencedaily.com     2+ mon ago

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of ...

Mayo Clinic researchers develop prediction tool for kidney stones

Mayo Clinic researchers develop prediction tool for kidney stones

eurekalert.org     2+ mon ago

By using these features to develop a Recurrence of Kidney Stone online prediction tool, researchers were able to improve upon known criteria for future stone formation. By entering...

Researchers develop a new method for turning skin cells into pluripotent stem cells

eurekalert.org     9+ mon ago

Credit: Otonkoski Lab / University of Helsinki Our bodies consist of many different kinds of cells, each with their own role. The Japanese scientist Shinya Yamanaka had made earlier the discovery, ear...

Stem cell researchers develop promising technique to generate new muscle cells in lab

Stem cell researchers develop promising technique to generate new muscle cells in lab

eurekalert.org     4+ mon ago

Stem cell researchers develop promising technique to generate new muscle cells in lab IMAGE: UTHealth stem cell researchers, from the left, are Nadine Matthias, DVM; Jianbo Wu, Ph...

Stem cell researchers develop promising technique to generate new muscle cells in lab

sciencedaily.com     4+ mon ago

Stem cell researchers develop promising technique to generate new muscle cells in lab To help patients with muscle disorders, scientists have engineered a new stem cell line to study the conversion o...

In their DNA: Rotator cuff stem cells more likely to develop into fat cells

sciencedaily.com     2+ mon ago

Why are fat deposits more likely to occur after tears of the shoulder's rotator cuff, compared to other types of muscle injuries? An increased propensity of stem cells within with rotator cuff muscles...

Researchers identify human skeletal stem cells

eurekalert.org     7+ mon ago

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CWRU scientists develop new method to more efficiently generate brain stem cells

eurekalert.org     6+ mon ago

Technique improves understanding of myelin disease; expands ability to screen potential therapies for rare pediatric brain disorder IMAGE: These are mutant PMD oligodendrocytes rescued with drug-like...

NUS researchers confine mature cells to turn them into stem cells

eurekalert.org     9+ mon ago

E-Mail IMAGE: Figure: A schematic showing the growth of a spherical cluster of stem cells from a mature cell on a confined substrate. Fibroblast cells that are confined to rectangular areas and... ...

Mayo Clinic researchers review modern cases of leprosy

eurekalert.org     2+ mon ago

Mayo Clinic Print E-Mail ROCHESTER, Minn. -- Leprosy has a history that has spanned centuries and societies across the globe. Yet, it continues to be a problem -- e...

Researchers develop new devices to test retinal cells

eurekalert.org     5+ mon ago

IMAGE: Farhad Farjood is the lead author on a study that describes new methods to mechanically stress retinal cells. view more LOGAN, UTAH -- Researchers at Utah State University have developed new d...

Stem cells help mice to develop super-sensitive sniffers

nature.com     2+ mon ago

By genetically engineering mice, Federico Calegari at the Technical University of Dresden, Germany, and his colleagues prompted the stem cells in the animals' brains to divide faster than usual. This ...

Researchers develop mini kidneys from urine cells

Researchers develop mini kidneys from urine cells

eurekalert.org     1+ mon ago

Scientists from Utrecht University, University Medical Center Utrecht and Hubrecht Institute have successfully created kidney organoids from urine cells. This could lead to a wide ...

Scientists reprogram T Cells to target autoimmune diseases

engadget.com     9+ mon ago

Scientists reprogram T Cells to target autoimmune diseases The non-viral technique is promising more specific therapies. ...

Researchers identify mesenchymal stem cells (MSCs) in human arteries

eurekalert.org     9+ mon ago

The Mount Sinai Hospital / Mount Sinai School of Medicine Share E-Mail Media advisory: To contact senior author Jason Kovacic, MD, PhD, Associate Professor of Medicine, Icahn School of Medicine at M...

Researchers engineer more efficient Cas12a variants

phys.org     2+ mon ago

Researchers engineer more efficient Cas12a variants February 12, 2019 by Bob Yirka, Phys.org report Credit: CC0 Public Domain ...

UC San Diego Researchers Create Spinal Cord Stem Cells

patch.com     8+ mon ago

UC San Diego Researchers Create Spinal Cord Stem Cells Spinal cord neural stem cells made from human pluripotent stem cells could eventually advance to human clinical trials, according to UCSD. ...

More success with adult stem cells

More success with adult stem cells

onenewsnow.com     1+ mon ago

petri dish stem cell research A cancer treatment using adult stem cells shows potential for also helping people with HIV. A patient in London contracted HIV in 2003 then developed...

Israeli researchers develop revolutionary space imaging system

xinhuanet.com     3+ mon ago

JERUSALEM, Dec. 23 (Xinhua) -- Israeli researchers developed an imaging system based on a synthetic aperture that stands to revolutionize the economics and imagery available from space-based cameras, ...

Researchers develop high-level gas detection system

phys.org     2+ mon ago

A new gas detector, developed by researchers at UBC's Okanagan campus, enables highly accurate odour analysis for so many different applications it has been nicknamed the 'arti...

Mayo Clinic researchers uncover methods to quantify the yips and golfer's cramp

eurekalert.org     9+ mon ago

E-Mail SCOTTSDALE, Ariz. -- Almost every golfer knows the feeling. Minutes after a picture-perfect drive down the fairway, a cascade of inexplicable missed putts leads to a disappointing triple boge...

Mayo Clinic researchers identify gene types driving racial disparities in myeloma

eurekalert.org     6+ mon ago

ROCHESTER Minn. -- Researchers at Mayo Clinic have identified three specific gene types that account for a known two-to-three-fold increase in myeloma diagnoses among African-Americans. Researchers al...

Mayo researchers develop new genetics-based prognostic tool for myelodysplastic syndrome

eurekalert.org     6+ mon ago

ROCHESTER, Minn. - Researchers at Mayo Clinic have developed a new genetics-based prognostic tool for myelodysplastic syndrome. Their findings are published in the October print issue of Mayo Clinic P...

Texas researchers seek to develop algae bloom warning system

sfgate.com     8+ mon ago

Image 1 of 8 In an Oct. 2006 photo, decaying fi...

Researchers characterize 'mutational burden' of human induced pluripotent stem cells

eurekalert.org     8+ mon ago

Researchers characterize 'mutational burden' of human induced pluripotent stem cells By identifying and characterizing specific types of mutations in individual cell lines, using a co...

Scientists use CRISPR to make stem cells invisible to immune system

engadget.com     2+ mon ago

Scientists use CRISPR to make stem cells invisible to immune system The new technique prevents the body from rejecting cells. ...

UMN researchers use 3D technology to identify optimal stem cells for transplantation

eurekalert.org     6+ mon ago

Groundbreaking science and technology come together to find potential answers for conditions such as muscular dystrophy MINNEAPOLIS, MN- October 4, 2018- Muscular dystrophy is a condition which cause...

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