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Intervening in glial cells protects neurons in Parkinson's model

https://www.eurekalert.org/pub_releases/2019-02/bifr-iig020719.php
See More From: eurekalert.org   ( Science & Technology )

Feb 12, 2019 12:00 AM 2+ mon ago

Intervening in glial cells protects neurons in Parkinsons model

Buck researchers identify crosstalk between dopaminergic neurons and glial cells in fruit flies providing a potential new target for preventative treatment

Loss of dopaminergic neurons is a hallmark of Parkinson's disease pathology. When dopaminergic neurons are stressed, they send out a call for help to nearby glial cells that are tasked with providing neuronal support, protection and nourishment. Under particular molecular conditions, those calls for help can over-activate the glial cells, resulting in a cascade of inflammatory signaling that eventually contributes to the degradation of these neurons over time. Working in two fruit fly models of Parkinson's disease, researchers at the Buck Institute have characterized a novel molecular mechanism that orchestrates such a harmful cascade of inflammatory signaling and demonstrated that its disruption protects neurons as they age. The research, published in Cell Reports, provides a new framework for understanding ...

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Defective glial cells can push neurons toward Parkinson's disease

sciencedaily.com     3+ mon ago

A team of scientists have discovered that astrocytes are linked to the buildup of a toxic protein that is one the hallmarks of Parkinson's disease. The work suggests an important role for glial cells ...

New gene therapy reprograms brain glial cells into neurons

eurekalert.org     5+ mon ago

Penn State Print E-Mail A new gene therapy can turn certain brain glial cells into functioning neurons, which in turn could help repair the brain after a stroke ...

Defective glial cells can push neurons toward Parkinsons disease

Defective glial cells can push neurons toward Parkinson's disease

eurekalert.org     3+ mon ago

New study suggests an important role for glial cells in Parkinson's disease and offers potential new therapeutic targets. "Our overall results completely turn our previous view of...

New gene therapy reprograms brain glial cells into neurons

sciencedaily.com     5+ mon ago

Summary: A new gene therapy can turn certain brain glial cells into functioning neurons, which in turn could help repair the brain after a stroke or during neurological dis...

How glial cells develop in the brain from neural precursor cells

sciencedaily.com     4+ mon ago

A research team studied how glial cells develop in the brain from neural precursor cells. They discovered that differentiation involves three stages and that three proteins in the cell nucleus, so-cal...

How glial cells develop in the brain from neural precursor cells

eurekalert.org     4+ mon ago

Mainz University Medical Center publishes new findings that contribute to our understanding of neurodegenerative disorders IMAGE: These are astrocytes grown in a culture dish, stained for the astrocy...

Neurons Grown in the Lab Strikingly Similar to Brain Cells

genengnews.com     3+ mon ago

Nerve cells made from fibroblasts have similar epigenomes as neurons from the brain, advancing the possibility of precision medicine for neurological diseases. A critical component to advancing drug ...

Faulty glial cells are at the center of Huntington?s disease

Faulty glial cells are at the center of Huntington?s disease

futurity.org     4+ mon ago

Support cells in the brain are key contributors to Huntington s disease, according to a new study. The research gives scie...

Fish 'umbrella' protects stem cells from sun

eurekalert.org     10+ mon ago

Credit: Zon Lab/HHMI/Boston Children's Hospital/Harvard Stem cells like it dark. In certain fish and frogs, cellular "umbrellas" shade fragile stem cells from the sun's harmful rays. The discovery, p...

Simple drug combination creates new neurons from neighboring cells

Simple drug combination creates new neurons from neighboring cells

eurekalert.org     2+ mon ago

Penn State Print E-Mail IMAGE: A simple treatment using four small molecules converts human astrocytes - a common type of cells in the nervous system - into new ne...

Stem cells from hair follicles have potential to repair damaged neurons in mice

sciencedaily.com     21+ hour, 21+ min ago

Stem cells that yield pigment-producing cells also regenerate the myelin sheath that coats neurons A subset of the stem cells in hair follicles have the potential to regenerate the coating that insul...

Brain cells responsible for removing damaged neurons after injury identified

sciencedaily.com     9+ mon ago

Summary: Researchers have discovered that microglia, specialized immune cells in the brain, play a key role in clearing dead material after brain injury. The study reveals that microglia gobble up the...

Neurons from stem cells may stop seizures, improve cognitive function

upi.com     4+ mon ago

Dec. 20 (UPI) -- New stem cells could bring a cure for seizures and boost to cognitive function in the brain for some patients, new research says. A study published Tuesday in the Proceedings of the ...

Actin cytoskeleton remodeling protects tumor cells against immune attack

eurekalert.org     6+ mon ago

Cancer cells have evolved multiple escape strategies to circumvent the body's immune defenses such as the attack by Natural Killer (NK) cells which normally swiftly kill abnormal cells by releasing cy...

Actin cytoskeleton remodeling protects tumor cells against immune attack

sciencedaily.com     6+ mon ago

Cancer cells have evolved multiple escape strategies to circumvent the body's immune defenses such as the attack by Natural Killer (NK) cells which normally swiftly kill abnormal cells by releasing cy...

Researchers identify brain cells responsible for removing damaged neurons after injury

eurekalert.org     10+ mon ago

E-Mail IMAGE: Microglia (red) gradually clear away the neuronal debris (green) produced following damage to the optic nerve. view more Credit: Norris et al., 2018 Researchers at the Univer...

Scientists accidentally reprogram mature mouse GABA neurons into dopaminergic-like neurons

eurekalert.org     6+ mon ago

Attempting to make dopamine-producing neurons out of glial cells in mouse brains, a group of researchers instead converted mature inhibitory neurons into dopaminergic cells. Their findings, appearing ...

Scientists accidentally reprogram mature mouse GABA neurons into dopaminergic-like neurons

sciencedaily.com     6+ mon ago

Attempting to make dopamine-producing neurons out of glial cells in mouse brains, a group of researchers instead converted mature inhibitory neurons into dopaminergic cells. Their findings reveal that...

Discovery of the genetic conductor of brain stem cells

Discovery of the genetic 'conductor' of brain stem cells

eurekalert.org     1+ mon ago

A new study by SISSA identifies the gene which regulates the production ratio of neurons and support cells during cerebral cortex development IMAGE: From neurostem cells to astroc...

Watching neurons in action

sciencedaily.com     8+ mon ago

Summary: Scientists have devised a way of observing the working of single neurons in unsurpassed detail in a live animal. Share: ...

Watching neurons in action

eurekalert.org     8+ mon ago

Share Print E-Mail Our brain cells control every aspect of our lives - from the movements we make to the memories we form. But capturing the activity of neurons in the form of el...

Surprise finding in neurons

eurekalert.org     8+ mon ago

E-Mail IMAGE: Immunofluorescence image from the cerebellar cortex region of bipolar patients that shows proteins of human herpesviruses (red) in Purkinje neurons. Astrocytes are stained green. ...

Discovery of the genetic 'conductor' of brain stem cells

sciencedaily.com     1+ mon ago

A new study identifies the gene which regulates the production ratio of neurons and support cells during cerebral cortex development Our brain comprises 85 billion nerve cells and just as many so-cal...

Interaction between bacteria and immune cells protects the intestinal barrier

sciencedaily.com     2+ mon ago

Conditions such as Crohn's disease or ulcerative colitis, a poor diet, overuse of certain drugs and stress harm the intestinal barrier and cause inflammation. An international study on mice has discov...

Palisades Boxing Gym Helping with Parkinsons

nbclosangeles.com     10+ mon ago

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Man shot, injured while intervening in argument in Utah

deseretnews.com     2+ day ago

The shooting was reported about 8:15 p.m. in the area of 3850 Benview Drive in West Valley City. It started when a man crossed the street to where people were fighting, according to West Valley Police...

Potent compound found in red wine kills lung-cancer cells and even PROTECTS against tumours

dailymail.co.uk     6+ mon ago

A potent compound found in red wine kills lung cancer cells and even protects against tumours, research suggests. The compound even prevented the disease developing when given to rodents exposed to a...

The White House roadmap for intervening in Venezuela

axios.com     7+ mon ago

...

Man shot, injured while intervening in argument in Utah

Man shot, injured while intervening in argument in Utah

ksl.com     2+ day ago

The shooting was reported about 8:15 p.m. in the area of 3850 Benview Drive in West Valley City. It started when a man crossed the street to where people were fighting, according t...

Rhode Island weighs intervening in troubled Providence schools

bostonglobe.com     2+ day ago

PROVIDENCE - Aides to Governor Gina Raimondo and Providence Mayor Jorge Elorza have begun discussing intervention strategies for the city's struggling public school system, a district that has been pl...

Discovered interaction between bacteria and immune cells protects the intestinal barrier

Discovered interaction between bacteria and immune cells protects the intestinal barrier

eurekalert.org     2+ mon ago

Universidad Complutense de Madrid Print E-Mail IMAGE: The result opens new avenues for the treatment of disorders such as ulcerative colitis or Crohn's disease. vi...

Walk for Parkinsons at Cardiff Bay

barry-today.co.uk     9+ mon ago

Members of the Vale of Glamorgan Parkinson s Support Group took part in a sponsored walk across Cardiff Bay on Saturday, June 16. Members could choose from a 2.5 mile or six-mile sponsored walk sta...

Rhode Island weighs intervening in troubled Providence schools

msn.com     2+ day ago

The first lady welcomed children to the White House for the annual Easter Egg Roll in a $4,995 blue suede Michael Kors trench coat dress. PROVIDENCE - Aides to Governor Gina Raimondo and Providence M...

Passerby injured while intervening in assault on Jew in Germany

Passerby injured while intervening in assault on Jew in Germany

israelnationalnews.com     2+ mon ago

A man who tried to prevent a suspected anti-Semitic assault at a German train station was severely beaten by the alleged culprit. ...

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