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Cross-species cancer comparison uncovers new drug targets, study reveals

https://www.eurekalert.org/pub_releases/2019-02/uog-ccc021219.php
See More From: eurekalert.org   ( Science & Technology )

Feb 12, 2019 12:00 AM 2+ mon ago

Cross-species cancer comparison uncovers new drug targets, study reveals

Mucosal melanoma arises in non-skin locations such as sinuses, nasal passages and mouth. The research team sequenced the genomes of mucosal melanoma tumours from 46 humans, 65 dogs and 28 horses and discovered a handful of genes that were commonly mutated in all species.These genetic similarities point to the drivers of the disease -- key information that will lead to using biologically relevant drug targets....

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Cancer comparison across species highlights new drug targets

sciencedaily.com     2+ mon ago

Cancer genes in mucosal melanoma, a rare and poorly understood subtype of melanoma, have been compared in humans, dogs and horses for the first time. Researchers sequenced the genomes of the same canc...

Cancer comparison across species highlights new drug targets

Cancer comparison across species highlights new drug targets

eurekalert.org     2+ mon ago

Scientists discover key genes for mucosal melanoma in humans, dogs and horses that help prioritize targets for new cancer therapies Cancer genes in mucosal melanoma, a rare and po...

New cancer drug targets mutations

New cancer drug targets mutations

nbcnews.com     4+ mon ago

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New lab study reveals how breast cancer drug can accelerate cancer cell growth

eurekalert.org     11+ mon ago

New lab study reveals how breast cancer drug can accelerate cancer cell growth...

New drug targets for BRCA-driven cancer uncovered

New drug targets for BRCA-driven cancer uncovered

eurekalert.org     3+ mon ago

Preclinical study yields previously unreported, potent and generalizable hits representing potential drug targets for hereditary breast, ovarian cancer BRCA1 and BRCA2 ("BReast CA...

Scientists identify cancer drug targets

news.com.au     1+ week ago

Hundreds of opportunities for new drugs to precisely kill cancer cells but leave healthy tissue unharmed have been identified by scientists. Scientists have identified hundreds of opportunities for n...

New cancer drug targets accelerate path to precision medicine

New cancer drug targets accelerate path to precision medicine

eurekalert.org     2+ week ago

Researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer's survival In one ...

Mapping oesophageal cancer genes leads to new drug targets

Mapping oesophageal cancer genes leads to new drug targets

eurekalert.org     2+ mon ago

Mutations that cause oesophageal adenocarcinoma (OAC) have been mapped in unprecedented detail - unveiling that more than half could be targeted by drugs currently in trials for ot...

Mapping esophageal cancer genes leads to new drug targets

sciencedaily.com     2+ mon ago

Mutations that cause esophageal adenocarcinoma (OAC) have been mapped in unprecedented detail -- unveiling that more than half could be targeted by drugs currently in trials for other cancer types. T...

'Hijacked' cell response to stress reveals promising drug targets for blood cancer

eurekalert.org     9+ mon ago

NYU Langone Health / NYU School of Medicine Share E-Mail A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for pr...

'Hijacked' cell response to stress reveals promising drug targets for blood cancer

sciencedaily.com     9+ mon ago

Summary: A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study...

New method reveals how well cancer drugs hit their targets

eurekalert.org     9+ mon ago

Credit: Erik Sahai Scientists have developed a technique that allows them to measure how well cancer drugs reach their targets inside the body. It shows individual cancer cells in a tumour in real tim...

New study targets Achilles heel of pancreatic cancer, with promising results

New study targets Achilles' heel of pancreatic cancer, with promising results

eurekalert.org     1+ week ago

VIDEO: New study targets Achilles' heel of pancreatic cancer, with promising results view more The findings, published in Nature on April 17, 2019, show that pancreatic stellate c...

New study targets Achilles' heel of pancreatic cancer, with promising results

sciencedaily.com     1+ week ago

Researchers discover a potential therapeutic target for deadly cancer Advanced pancreatic cancer is often symptomless, leading to late diagnosis only after metastases have spread throughout the body....

New drug blocks pancreatic cancer growth in mice, study finds

eurekalert.org     7+ mon ago

Cedars-Sinai Medical Center Print E-Mail LOS ANGELES (Sept. 25, 2018) -- A newly developed drug can prevent the most common type of pancreatic cancer from growin...

New drug blocks pancreatic cancer growth in mice, study finds

sciencedaily.com     7+ mon ago

Summary: A newly developed drug can prevent the most common type of pancreatic cancer from growing and spreading in laboratory mice, according to a new study. The study als...

Study uncovers new hurdle for developing immunotherapies

eurekalert.org     7+ mon ago

University of Notre Dame Print E-Mail IMAGE: Brian Baker, the John A. Zahm, C.S.C., Professor of Structural Biology and chair of the Department of Chemistry and Biochemistry view ...

Zika virus targets brain cancer in vaccine study

foxnews.com     7+ mon ago

CDC study found one in seven children born to mothers infected with the virus during pregnancy developed some kind of health problem by the time they turned one, includ...

Study reveals how gene activity shapes immunity across species

eurekalert.org     6+ mon ago

By sequencing genes from over a quarter of a million cells across six mammalian species, researchers at the Wellcome Sanger Institute, EMBL's European Bioinformatics Institute and collaborators, have ...

Marcia Cross reveals she s recovering from anal cancer

pagesix.com     6+ mon ago

Desperate Housewives alumna Marcia Cross is on the road to recovery following a battle with anal cancer. The 56-year-old actress posted to Instagram ...

Cryo-EM reveals interaction between major drug targets

eurekalert.org     10+ mon ago

...

New test uncovers metabolic vulnerabilities in kidney cancer

eurekalert.org     7+ mon ago

Credit: UT Southwestern DALLAS - Aug. 28, 2018 - In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally reco...

New study uncovers the interaction of calcium channels

eurekalert.org     6+ mon ago

IMAGE: Prof. Byung-Chang Suh (Department of Brain & Cognitive Sciences) and his PhD student Jun-Hee Yeon (left) view more A research team led by DGIST Professor Byung-Chang Suh at the Department of B...

New study uncovers the interaction of calcium channels

sciencedaily.com     6+ mon ago

Researchers have identified the interactions of the combinants among calcium channel proteins that exist in nerve and heart cells. The result opened a new path of developing treatments for high blood ...

Measuring cancer cell ?fitness? reveals drug susceptibility

Measuring cancer cell ?fitness? reveals drug susceptibility

news.mit.edu     4+ mon ago

By studying both the physical and genomic features of cancer cells, MIT researchers have come up with a new way to investigate why some cancer cells survive drug treatment while ot...

Using a promiscuous inhibitor to uncover cancer drug targets

phys.org     3+ week, 4+ min ago

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within canc...

Worcester Polytechnic Institute Study Uncovers New Link between?

virtual-strategy.com     6+ mon ago

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Using a promiscuous inhibitor to uncover cancer drug targets

eurekalert.org     3+ week, 17+ min ago

Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within canc...

Using a promiscuous inhibitor to uncover cancer drug targets

sciencedaily.com     2+ week ago

Scientists have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells. Scientists at Harvard Medical School and the Dana-Fa...

Large U.S. study targets prostate cancer in black men

upi.com     9+ mon ago

Large U.S. study targets prostate cancer in black men By HealthDay News...

DNA study reveals there are six distinct species of Tiger

dailymail.co.uk     6+ mon ago

There are six types of tiger still remaining, ecologists have concluded, in a study which could boost efforts to save the big cat from extinction. There are fewer than 4,000 tigers left in the wild a...

Marcia Cross Reveals Her Hair-Loss Struggle Post-Cancer

popsugar.com     6+ mon ago

Marcia Cross Reveals Her Hair-Loss Struggle Post-Cancer 0 Shares Marcia Cross entertained us on the small screen for years on shows like Mel...

Study: Prostate drug finasteride safely lowers cancer risk

upi.com     3+ mon ago

Finasteride, best known as the enlarged-prostate medicine Proscar, is a safe, effective way to reduce the risk of prostate cancer, according to long-term findings from the Prostate Cancer Prevention T...

Study in mice uncovers an unknown pathway for breast cancer tumors to recur

Study in mice uncovers an unknown pathway for breast cancer tumors to recur

eurekalert.org     1+ hour, 33+ min ago

DURHAM, N.C. -- For many women who thought they had beaten breast cancer, the news that it has roared back years later comes as an especially cruel diagnosis with no clear answers ...

Largest census of cancer genes to help understand drug targets

eurekalert.org     6+ mon ago

Researchers at the Wellcome Sanger Institute have created the first comprehensive summary of all genes known to be involved in human cancer, the "Cancer Gene Census". Describing all genes strongly imp...

DNA 'webs' aid ovarian cancer metastasis, study reveals

eurekalert.org     4+ mon ago

Rockefeller University Press Print E-Mail IMAGE: Ovarian cancer cells (red) can become trapped in sticky webs of DNA (green) released by immune cells known as neutrophils. view mo...

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